MD, Yale University
Academic Rank: Professor
Phone: 314-577-8764 Fax: 314-577-8125
Primary Area of Cardiovascular Research Interest
Lipotoxic diseases, especially with respect to liver injury and the role of the liver in systemic lipotoxic injury (eg vascular disease)
Related Areas of Cardiovascular Research Interest
-Mechanisms of trans -fat induced cellular injury in relationship to the pathogenesis of nonalcoholic steatohepatitis.
Summary of Cardiovascular Research Interest
We have established a mouse model of nonalcoholic steatohepatitis based on feeding mice a high trans -fat diet. Through its role in synthesizing, metabolizing and secreting lipids, the liver plays a central role in lipid metabolism. Although our work focuses specifically on the mechanisms of liver injury during trans -fat feeding, the metabolic changes that we have observed (hypercholesterolemia, hepatic insulin resistance) have broader implications, especially with respect to cardiovascular disease, that warrant further investigation.