David Wang, M.D., Ph.D.
M.D., Ph.D., Shanghai Second Medical University, China (Medicine/Biochemistry)
Department: Internal Medicine
Academic Rank: Professor
Phone: 314-977-8737 Fax: 314-977-9909
Primary Area of Cardiovascular Research Interest
-Molecular physiology of hepatic cholesterol and bile acid metabolism
-Genetic regulation of intestinal absorption of cholesterol and fatty acids
Related Areas of Cardiovascular Research Interest
-Physical-chemistry of lipids
-Pathophysiology of gallstones, nonalcoholic fatty liver disease, and the metabolic syndrome
-Role of nuclear receptors in biliary lipid metabolism
Summary of Cardiovascular Research Interest
Our research interests are (i) to identify, localize, and estimate the lithogenic effects of pathophysiologically relevant gallstone (LITH) genes; to understand at a fundamental level the genetic mechanisms of cholesterol gallstones; and to investigate the genotypes and phenotypes of LITH genes in mice and eventually in humans; (ii) to study the genetic and physical-chemical factors that could determine the intestinal absorption efficiency of cholesterol and fatty acids; (iii) to elucidate the effect of nuclear receptors on biliary lipid metabolism; (iv) to understand hepatic cholesterol and bile acid metabolism at a molecular level; and (v) to study pathophysiology of the metabolic syndrome with special focus on the relationship between insulin resistance and nonalcoholic fatty liver disease, and to explore novel approaches for their prevention and treatment.