Jianguo Liu

Ph.D., Peking University (Cardiovascular Immunology)

Department: Internal Medicine/Molecular Microbiology and Immunology

Academic Rank: Assistant Professor

Phone: 314-977-7171 Fax: 314-771-3816

E-mail: jliu9@slu.edu

Lab Web Page Links:



Primary Area of Cardiovascular Research Interest

-Innate immune regulation in cardiovascular diseases
-Macrophage biology and chronic inflammation

Related Areas of Cardiovascular Research Interest

-Cytokine and chemokine regulation in macrophages in atherosclerosis

Summary of Cardiovascular Research Interest

Our laboratory is currently studying the role of cytokine and chemokine in human diseases, with particular interest in exploring the effects of innate immunity in atherosclerosis and chronic inflammation. Since atherosclerosis is a chronic inflammatory disease characterized by arterial lesions composed of cholesterol, immune cells and fibrosis, we are interested in the molecular mechanisms by which chemokines secreted from infiltrating macrophages and vascular smooth muscle cells direct migration of inflammatory immune cells in the wall of injured blood vessels, and the role of inflamed macrophages in the pathogenesis of atherosclerosis. We are also interested in the effects of apoE on cytokine expression and subsequent affects on local immune responses. Other ongoing projects in our laboratory include: the role of the IL-12 cytokine family in protective immunity directed against Mycobacterial tuberculosis; the role of IL-10 in the pathogenesis of juvenile idiopathic arthritis and SLE; and the molecular mechanisms of chemokine-mediated tumor growth and metastasis.